Dec. 12th 2017

Agenda

• Activity 3.1.2: X-ray vision
• Staining cells next week

Resource links:

• Human Anatomy Online: Broken Bones and Fractures http://www.innerbody.com/image/skel06.html (Links to an external site.)
• WebMD: Understanding Fractures http://www.webmd.com/a-to-z-guides/understanding-fractures-basic-information

Agenda:

• Meets/Exceeds Test Prep Unit 2
• TEST DATE NEXT Friday DECEMBER 8th 

Meets Links:

Question 1: 
Molecular Techniques for PTC 
http://bioinformatics.dnalc.org/ptc/animation/ptc.swf
AND
PLEASE LOOK AT YOUR SRS SHEET FOR THE PTC LAB!!!!!


Question 2: 
Molecular logic of screening your PTC genes
http://bioinformatics.dnalc.org/ptc/animation/ptc.swf
(please click on results and discussions)

Question 3: 
Genetic Disorders
CHROMOSOMAL can be the following:
Turner, Down, Klinefelter, or Williams syndromes click here: 
http://learn.genetics.utah.edu/content/disorders/chromosomal/

SINGLE GENE can be the following:
Cystic Fibrosis, Maple Syrup Urine Disease, Huntington's Disease: 

http://learn.genetics.utah.edu/content/disorders/singlegene/

Question 4: Gene delivery tools- the following can be on the test: 
Retroviruses, Adenovirus, Adeno-associated virus, 

http://learn.genetics.utah.edu/content/genetherapy/tools/

Exceeds Link:

1. PCR Amplification:

PCR OVERVIEW http://learn.genetics.utah.edu/content/labs/pcr/

PCR CYCLE: http://www.sumanasinc.com/webcontent/animations/content/pcr.html

2. CRISPR Technology

Great overview: yourgenome.org 

Straight forward explanation: infographic (you get some points)

Comprehensive review: click on this infographic (you get more points for this type of explanation)

3. Molecular logic of of bitter taste perception.

http://learn.genetics.utah.edu/content/basics/ptc/

4. Amniocentesis and CVS:

Amniocentisis animation: 

http://www.cengage.com/biology/discipline_content/animations/amniocentesis_m.html

Amnio vs. CVS:

http://images.slideplayer.com/7/1738899/slides/slide_15.jpg

https://geneticcounseling.info/

Nov. 21st, 2017

Agenda:

Activity 2.1.5 Maternal and Child Health

Abnormal Karyotypes:  http://learn.genetics.utah.edu/content/disorders/chromosomal/

Part I: Prenatal Screening: Amniocentesis and Chorionic Villus Sampling (CVS)

• Great Overall Description of both procedures: https://drive.google.com/file/d/1Uniml_Ee79FmUzZq84YKZnuma0oqiQAV/view?usp=sharing

• American Pregnancy Association – Amniocentesis http://www.americanpregnancy.org/prenataltesting/amniocentesis.html
•  (Links to an external site.)
• American Pregnancy Association – Chorionic villus sampling http://www.americanpregnancy.org/prenataltesting/cvs.html (Links to an external site.)

 Part II: Prenatal Monitoring: Ultrasound

 View the video clip on ultrasound listed below:

Mayo Clinic: Fetal Ultrasound http://www.mayoclinic.com/health/ultrasound/MM00084 (Links to an external site.)


12. Research what can be learned about a fetus by looking at an ultrasound image by reading the information presented on Obstetric Ultrasound Scans at:  http://www.ob-ultrasound.net/

 (Links to an external site.)14. Read the National Geographic article 4-D Ultrasound Gives Video View of Fetuses in the Womb: http://news.nationalgeographic.com/news/2005/02/0225_050225_tv_ultrasound.html

 (Links to an external site.)15. Explore the 4D Ultrasound Scan Video Clips presented by Dr. Najeeb Layyous found at http://www.layyous.com/ultasound/ultrasound_video.htm

 (Links to an external site.)

Nov. 28 2016

Agenda:

• Activity 2.2.2: Reproductive Technology and Genetic Engineering
• Radiolab: CRISPR Technology
• MIT & CRISPR Video

Part 2: Resource Links for learning about CRISPR:

• The website on yourgenome.org provides the most information

• Nature magazine's infographic is straightforward and great

• Know your Neurons infographic goes deeper and more comprehensive

• The video on Vimeo is also very helpful for modifying and mutating genes using CRISPR

Part 3: 

• View the ArgosBiotech’s website, Cloning: A Timeline

• View University of Utah's website on what is cloning?

• Nation Human Genome Research Institute - Cloning fact sheet 

Learning Target(s)

I can ...

• analyze various perspectives on reproductive technologies and genetic engineering tools like CRISPR.

• demonstrate and model how the CRISPR system works to genetically alter DNA.  

• Finish Activity 2.2.1: Gene Therapy
• Socratic Seminar on Wednesday 

1. Visit the Genetic Science Learning Center (GSLC) Gene Therapy site

 (Links to an external site.) and read the three sections listed below.

• What is Gene Therapy?
• Choosing Targets for Gene Therapy
• Gene Delivery: The Key to Gene Therapy

3. Use your Student Response Sheet to complete the GSLC Space Doctor interactive found at   http://learn.genetics.utah.edu/content/genetherapy/doctor/ 

Part II: Debating Gene Therapy:  

Before reading the articules please click here: https://www.yourgenome.org/debates and pick the following:

• Review the website: Germline therapy:
• Consider the question in each site as you tally up your Yes's and No's and write them in your SRS or lab packet.

 (Links to an external site.)

Against the use of gene therapy.

• The New York Times – Patient Dies During a Trial of Therapy Using Geneshttp://query.nytimes.com/gst/fullpage.html?sec=health&res=9E06EED8173EF93AA1575AC0A96F958260 (Links to an external site.)
• Fox News – Boy Living in Bubble Develops Leukemia From Experimental Therapyhttp://www.foxnews.com/story/0,2933,317225,00.html (Links to an external site.)
• BBC News Magazine – Gene Doping: Sport’s Biggest Battle?http://www.bbc.com/news/magazine-25687002 (Links to an external site.)  
• The New York Times – 2nd Cancer is Attributed to Gene Used in FDA Testhttp://query.nytimes.com/gst/fullpage.html?res=9801E7DB1F31F934A25752C0A9659C8B63 (Links to an external site.)
• ABC News – Patient Death Latest Setback for Gene Therapyhttp://abcnews.go.com/Health/Story?id=3421869&page=1 (Links to an external site.)
• The New York Times – Trials are Halted on a Gene Therapyhttp://query.nytimes.com/gst/fullpage.html?res=9C01E7D9163BF937A35753C1A9649C8B63 (Links to an external site.)

In favor of gene therapy: 

• Biology News Net – Gene Therapy Shows Promise as Weapon Against HIVhttp://www.biologynews.net/archives/2009/02/23/gene_therapy_shows_promise_as_weapon_against_hiv.html (Links to an external site.)
• New Scientist - Gene Therapy Cures “Bubble Boy”http://www.newscientist.com/article/dn2124-gene-therapy-cures-bubble-boy.html (Links to an external site.)
• The New York Times – More Than Humanhttp://www.nytimes.com/2005/07/03/books/chapters/0703-1st-naam.html (Links to an external site.)
• New Scientist – Gene Therapy is First Deafness ‘Cure’http://www.newscientist.com/article/dn7003 (Links to an external site.)
• Stanford University Medical Center – Gene Therapy for Muscular Dystrophy Fixes Frail Muscle Cells in Animal Model http://www.eurekalert.org/pub_releases/2005-12/sumc-gtf122205.php (Links to an external site.)
• USA Today – Gene Therapy Experiments Improve Vision in Nearly Blindhttp://www.usatoday.com/tech/science/2008-04-28-3714044875_x.htm (Links to an external site.)

October 25th, 2017

Agenda:

• Activity 2.1.3 Test your own genes
• Website 1: PTC Labs: http://learn.genetics.utah.edu/content/basics/ptc/
• Website 2: Great Overview of the lab:  http://bioinformatics.dnalc.org/ptc/animation/ptc.swf

Part I: How PCR Works: Please create a flowchart on how PCR functions. Use highlighters, markers, and/or modeling supply. 

• The Flow of the PCR: http://learn.genetics.utah.edu/content/labs/pcr/

• Draw the PCR cycle link: https://www.thermofisher.com/us/en/home/life-science/pcr/elevate-pcr-research/pcr-video-library/pcr-animation.html

Week of October 24, 2017

Agenda:

• Activity 2.1.2 Copying our Genes
• https://docs.google.com/presentation/d/1lxoNVzSx8abFp2HYSym3XY5RCArbi5X0DHLlg5h2JTU/edit?usp=sharing

Part I: How PCR Works:

• PCR OVERVIEW http://learn.genetics.utah.edu/content/labs/pcr/
• PCR CYCLE: http://www.sumanasinc.com/webcontent/animations/content/pcr.html
• PCR CYCLE: https://www.thermofisher.com/us/en/home/life-science/pcr/elevate-pcr-research/pcr-video-library/pcr-animation.html

Part 2:  Overview of your lab tomorrow: Use the link to answer the questions.

• http://bioinformatics.dnalc.org/ptc/animation/ptc.swf

Part 3: Learn about tasting bitterness: 

• http://learn.genetics.utah.edu/content/basics/ptc

Week of October 16th

Agenda:

• Activity 2.1.1: Chronicles of a genetic counselor

• Presentation for Activity 2.1.1 Click Here
• Genetic counseling: https://www.youtube.com/watch?v=PZP45-WRLpo
• Genetic Counseling: http://explorehealthcareers.org/en/Career/53/Genetic_Counselor

Activity 2.1.1 Resources: 

Types of genetic inheritance: http://www.brusselsgenetics.be/p_397.htm

Duchenne Muscular Dystrophy:

MDA Organization: https://www.mda.org/disease/duchenne-muscular-dystrophy/overview
New Treatment for DMD: http://www.sciencedaily.com/releases/2015/10/151022141722.htm

Cystic Fibrosis: 
Utah Genetics: http://learn.genetics.utah.edu/content/disorders/singlegene/


Huntington's Disease:
HDSA Organization: http://hdsa.org/what-is-hd/

Down Syndrome: 
http://www.ndss.org/Down-Syndrome/

Alzheimer's Disease: 
http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp

Leber Hereditary optic neuropathy: 
http://lhon.org/lhon/LHON_101.html

Week of October 5th, 2017
Agenda:

• Unit 1 Meets/Exceeds Prep

• How much antibiotics is in your meat video

• The rise of superbugs

Unit 1 Meets Resources:
1. Antibiotics

Penicillin Links: 

• http://www.medicalnewstoday.com/articles/216798.php
• http://i.ytimg.com/vi/7UNmhvuvv2I/hqdefault.jpg (great Picture)

Tetracyclines:

• http://www.chm.bris.ac.uk/motm/tetracycline/antimicr.htm
• http://image.slidesharecdn.com/tetracycline-141117123807-conversion-gate01/95/tetracycline-6-638.jpg?cb=1416227925

Flouroquinolones:

• https://www.youtube.com/watch?v=eLs_2-zikV4 (great video)
• http://www.factive.com/images/healthcare/Mechanism_01.gif  (Great pic on Mechanism of action)

Sulfa antibiotics:

• http://www.nih.gov/researchmatters/march2012/03122012sulfa.htm
• http://chemistry.elmhurst.edu/vchembook/653sulfa.html

2. Anatomy of a Bacteria: 

• http://www.cellsalive.com/cells/bactcell.htm
• https://s-media-cache-ak0.pinimg.com/ (great picture!)

3. Reading Audiograms

• http://www.firstyears.org/lib/howtoread.htm (BEST overview!)

4. Sound Transduction

• http://www.sumanasinc.com/webcontent/animations/content/soundtransduction.html

Unit 1 Exceeds Resources:

1. Gram Staining:

• https://en.wikipedia.org/wiki/Gram_staining

2. ELISA

• Biorad Presentation: https://drive.google.com/file/d/0B-uPIvmZGNt-UmNFOFVfMV84Ylk/view?usp=sharing
• Bio-rad Link: http://www.bio-rad.com/LifeScience/jobs/2004/04-0522/04-0522_ELISA.html

3. Tube Dilutions:

• https://drive.google.com/file/d/0B-uPIvmZGNt-Szc5a0ZieVg0VmM/view?usp=sharing

4. Bacterial Meningitis:

• http://healthlifemedia.com/healthy/what-is-bacterial-meningitis/
• https://edc2.healthtap.com/ht-staging/user_answer/  (great picture)

Agenda: October 3rd:
Gram Staining:

• McGraw: http://highered.mheducation.com/olcweb/cgi/pluginpop.cgi?it=swf::530::530::/sites/dl/free/0073525502/930300/Gram_Stain.swf::Gram%20Stain
• Wikipedia: https://en.wikipedia.org/wiki/Gram_staining#/media/File:Gram_Stain_Procedure.png

Resource Links:

Structure and Function of Bacteria: 
http://www.cellsalive.com/cells/bactcell.htm

http://wikieducator.org/Bacterial_Structure

Penicillin:
http://www.medicalnewstoday.com/articles/216798.php

Tetracylcine: http://www.chm.bris.ac.uk/motm/tetracycline/antimicr.htm

Tetracycline image: http://image.slidesharecdn.com/tetracycline-141117123807-conversion-gate01/95/tetracycline-6-638.jpg?cb=1416227925

Fluoroquinolones: http://tmedweb.tulane.edu/pharmwiki/doku.php/fluoroquinolones

Fluoroquinolones video: https://www.youtube.com/watch?v=eLs_2-zikV4

Sulfa antibiotics:
http://www.nih.gov/researchmatters/march2012/03122012sulfa.htm

https://study.com/academy/lesson/inhibitors-of-metabolite-synthesis-how-sulfa-drugs-work.html


Gram Staining (why people say Gram+/-):
http://highered.mheducation.com/sites/007337525x/student_view0/exercise9/gram_stain.html


Learning Targets: