Activity 3.4.1 Personalized Medicine

Feb. 28th, 2018

Agenda:

• Activity 3.4.1 Personalized Medicine
• http://learn.genetics.utah.edu/content/precision/example/
• Nell's DNA sequence

Resources:

Bioserver:

http://www.bioservers.org/bioserver/

SNPs make sense:

http://learn.genetics.utah.edu/content/precision/snips/

What is Acute Lymphoblastic Leukemia (ALL):  

https://medcomic.com/medcomic/acute-lymphoblastic-leukemia/https://www.cancer.gov/types/leukemia/patient/child-all-treatment-pdq

 (Links to an external site.)at http://learn.genetics.utah.edu/content/pharma/

PLTW Cancer Center – Bioinformatics Lab

DNA Sequence Data: partial TPMT gene (840 base pairs) – acute lymphoblastic leukemia (ALL) patients

Renee

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacagg gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgaac

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

Maggie

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacaga gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgagc

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

Jada

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacagg gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgagc

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

Su

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacaga gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgaac

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

5th patient:

Nell

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacaga gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgaac

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

Learning Target:

• I can determine how SNPs in my DNA sequence effect how I can metabolize different drugs that treat cancer. 

Feb 15th, 2018

Agenda:

• Unit 3 Meets/Exceeds Prep
• Finish up Skin Cancer lab

Meets Links:

Question 1: Cancer, Genes and Regulation

Cancer Presentation

P53 and Cancer

Question 2: Gene expression & DNA CHIP Analysis 

Microarray Animation 

Question 3: UVB damage and repair

Enzyme repair animation

look in 3.2.2 Skin cancer packet

Question 4: Clinical Trials

Clinical Trials Presentation Clinical

Exceeds Links:

Question 1: Features of cancer and normal cells

Use you activity 3.1.3: When cells loose control 

Question 2: UV and Skin Cancer

UVA and UVB Wavelength and Protection

Information on UVC

Information on SPF factors

Question 3: The three types of skin cancer

Three different types of skin cancers

Look in 3.2.2 Skin cancer packet

Question 4:  Viruses that cause cancer 

Presentation on Viruses that cause cancer

Agenda: 

Project 3.2.2: Skin Cancer Prevention

Helpful Links:DNA damage and repair

Yeast Life Cycle

Other helpful links:

How UV Damages DNA

Using Yeast in Biology

Agenda:

• Activity 3.4.3: Clinical Trials
• Clinical Trials Presentation please click here

Learning targets:

I can ....

• compare and contrast the major types of clinical trials and determine which are best to implement and conquer cancer.

Agenda: 

Project 3.2.2: Skin Cancer Prevention
Resource Link: 

Three types of skin cancer: http://www.sunsmart.com.au/skin-cancer/skin-cancer-types

American Skin Cancer Society: http://www.skincancer.org/

Images of different skin cancer: http://www.cancer.org/cancer/skincancer/galleries/skin-cancer-images

UVA, UVB, UVC: http://share.upmc.com/2014/07/infographic-abcs-uv-difference-uva-uvb-uvc/

 The story of Dan: http://www.skincheck.org/Page7.php

Skin Cancer/Diseases:

http://www.mayoclinic.org/diseases-conditions/skin-cancer/multimedia/melanoma/sls-20076095

Feb. 1st, 2018
Agenda:
Activity 3.2.4: Virology

Useful Links:
Viruses linked to cancer presentation (please use this one for the SRS)

NIH Viruses and cancer PDF (additional resource)