Date: December 15th,

Agenda:

• Activity 3.1.6: When cells lose control
• Immuno-staining wild type and cancer cells

Part I: Normal Cells Versus Cancer Cells

1. Obtain a Student Response Sheet from the teacher.

2. Answer Questions 1-4 on the Student Response Sheet as you watch the video “Cancer and the Cell Cycle” found at Emory University’s CancerQuest 

website: http://www.cancerquest.org/images/FLV/fullDocumentary/English/fullDocInterfaceEng.swf (Links to an external site.)

3. Brainstorm how you think mutations occur in proto-oncogenes and tumor suppressor genes that can lead to cancer.

4. Investigate how a proto-oncogene becomes an oncogene as you view the Annenberg Media’s animation “How a Proto-oncogene Becomes an Oncogene” found at: http://www.learner.org/courses/biology/archive/animations/hires/a_cancer2_h.html (Links to an external site.)

    Another Resource Link: http://www.hhmi.org/biointeractive/p53-gene-and-cancer

5. Answer question 5 on the Student Response Sheet.

6. Answer Question 6 on the Student Response Sheet as you watch the Annenberg Media’s animation “p53’s Role in the Cell” about how one particular tumor suppressor gene works, found at:http://www.learner.org/courses/biology/archive/animations/hires/a_cancer3_h.html (Links to an external site.)                      Another Resource Link: http://www.hhmi.org/biointeractive/p53-gene-and-cancer

Learning Targets:

I can ...

• compare and contrast cellular and molecular mechanisms of normal cells and cancer cells. 
• implement advanced molecular techniques to stain normal cells and cancer cells to study under my microscope.

December 9th

Agenda:
Meets/Exceeds Exam Prep
Avid will come next Tuesday to see our class


Meets Resource Links:

Question 1: PCR
http://learn.genetics.utah.edu/content/labs/pcr/


Question 2: Restriction enzyme HAE III works
http://bioinformatics.dnalc.org/ptc/animation/ptc.swf


Question 3: Genetic Disorders:
MDA Organization: https://www.mda.org/disease/duchenne-muscular dystrophy/overview

DMD: http://www.sciencedaily.com/releases/2015/10/151022141722.htm  

Cystic Fibrosis: http://learn.genetics.utah.edu/content/disorders/singlegene/cf/

Huntington's Disease:: http://hdsa.org/what-is-hd/

Down Syndrome:  http://www.ndss.org/Down-Syndrome/
Alzheimer's Disease:  http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp
Leber Hereditary optic neuropathy:  http://lhon.org/lhon/LHON_101.html

Question 4: Genetic engineering using vectors
http://learn.genetics.utah.edu/content/tech/genetherapy/


Exceeds Resource Links
Question 1:
DNA Microarray:  http://learn.genetics.utah.edu/content/labs/microarray/

Question 2: 
CRISPR Video: http://blog.openhelix.eu/?p=20308
CRISPR Diagram:  http://www.the-scientist.com/images/

Question 3:
Taste Perception: http://learn.genetics.utah.edu/content/inheritance/ptc/

Question 4: 
Amniocentesis and CVS: http://familydoctor.org/familydoctor
Amniocentesis Video: http://www.stanfordchildrens.org/en/topic/
CVS animation: http://www.cengage.com/biology/

Agenda: 3.1.4: When Cells Lab

DNA Microarray Virtual Lab

1. Obtain a Student Response Sheet from your teacher.

2. Go to the “DNA Microarray Virtual Lab” found at the University of Utah’s Learn.Genetics: Genetic Science Learning Center’s website:  http://learn.genetics.utah.edu/content/labs/microarray/ (Links to an external site.)

3. Click on the picture of the microarray to begin.

4. Click on “Chapter 3: The Experiment!” to begin the virtual experiment.

5. Answer the questions on your Student Response Sheet as you work through the virtual DNA microarray experiment.

6. Answer Conclusion questions 1 – 3.

Agenda: 

3.2.1: Lessons from a Fly

Resources:

Male/Female:
http://www.wikihow.com/Distinguish-Between-Male-and-Female-Fruit-Flies

Life Cycle:
http://skenderianscience.weebly.com/uploads/2/6/1/4/26143564/7822724_orig.jpg

Fly Fight Club: 
http://www.hms.harvard.edu/bss/neuro/kravitz/

Agenda: December 1st, 2015

Activity 3.13a: Hormones gone wild

BBC Two: Hormones and the brain

Resources Online Links:

• Nemours Foundation- A Body Basics Article: Endocrine Systemhttp://kidshealth.org/teen/your_body/body_basics/endocrine.html (Links to an external site.)
• The Hormone Foundation – Endo 101: Endocrine Glandshttp://www.hormone.org/Endo101/page2.cfm (Links to an external site.)
• Medline Plus – Medical Dictionary: Hormoneshttp://www.nlm.nih.gov/medlineplus/hormones.html (Links to an external site.)
• Tour of the Endocrine System http://www.innerbody.com/image/endoov.html (Links to an external site.)
• Biology at University of Cincinnati Clermont College: Endocrine Systemhttp://www.biology.clc.uc.edu/courses/bio105/endocrin.htm (Links to an external site.)

November 24th, 2015

Agenda:

• Start Activity 3.1.2: Diagnostic Imaging

• BBC Two Horizons:  Defeating Cancer

Links/Resources:

• Presentation on Diagnostic Imaging

Draft of a concept map:

November 22nd 2015

Agenda:

• Activity 3.1.1: Who is Affected by Cancer

• BBC Two Horizons:  Defeating cancer

• Using Algae to defeat cancer: https://www.youtube.com/watch?v=KEHdZzc6wsI

Links/Resources:

• Case File On Mike Rivera: Please read this file 

• Mike Rivera's Cancer Cells: Origin Video

• Tapeworm Cancer:  http://www.huffingtonpost.com/entry/tape-worm-cancer

• Barefoot Surgery: https://www.youtube.com/watch?v=uKr4tMXJEhE

November 16th, 2014

Activity 2.2.3: Genetic Therapy

Procedure

Part I: A Glimpse into the Future

View the clip of human cloning: https://www.youtube.com/watch?v=dfqwUlnsGvY

 Part II: Sex Selection

Mr. and Mrs. King have three healthy boys. Although Mrs. King loves her sons, she is tired of being the only female in the house. She and her husband have decided they want to have another child, but this time, they are looking to science to help them conceive a girl.

Use the Internet to research medical interventions that can help Mrs. King fulfill her dream of having a daughter. Investigate the new CRISPR that provide parents the opportunity to choose the gender of their children.

CRISPR Human Genetic Engineering:

http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/

http://www.digitaltrends.com/cool-tech/genetically-engineered-human-embryo-crispr/

http://www.pbs.org/wgbh/nova/next/evolution/crispr-gene-drives/

IVF: 

http://www.sumanasinc.com/webcontent/animations/content/invitrofertilization.html

Part III: Designer Babies

Maya and Armond Harris have been trying for years to get pregnant. Their last two attempts at in vitro fertilization (IVF) have been unsuccessful. The doctor suggests using preimplantation genetic diagnosis (PGD) to analyze chromosomes and pinpoint the embryos that have a greater chance of surviving. Maya and Armond are hesitant to select particular embryos – they feel as if this is putting them one step closer to designing their child.

Time article Designer Babies available: http://www.time.com/time/magazine/article/0,9171,17696,00.html

 (Links to an external site.)

Part IV: Reproductive Cloning

Marion Waters is desperate to have a child of her own. Despite multiple fertility treatments, she has never been able to conceive. She is a single woman and feels her opportunity to have a child is quickly coming to a close. She sees a report on cloning on the news and begins to wonder if this technology will ever be available to help women in her situation.

View the ArgosBiotech’s website, Cloning: A Timeline, found at  http://www.argosbiotech.de/700/timelines/cloning.htm

 (Links to an external site.)

Explore the science behind reproductive cloning by reading the following articles.Learn.Genetics – What is Cloning:  http://learn.genetics.utah.edu/content/cloning/whatiscloning/

 (Links to an external site.National Human Genome Research Institute – Cloning Fact Sheet: http://www.genome.gov/25020028 (Links to an external site.)