Date: December 15th,

Agenda:

• Activity 3.1.6: When cells lose control
• Immuno-staining wild type and cancer cells

Part I: Normal Cells Versus Cancer Cells

1. Obtain a Student Response Sheet from the teacher.

2. Answer Questions 1-4 on the Student Response Sheet as you watch the video “Cancer and the Cell Cycle” found at Emory University’s CancerQuest 

website: http://www.cancerquest.org/images/FLV/fullDocumentary/English/fullDocInterfaceEng.swf (Links to an external site.)

3. Brainstorm how you think mutations occur in proto-oncogenes and tumor suppressor genes that can lead to cancer.

4. Investigate how a proto-oncogene becomes an oncogene as you view the Annenberg Media’s animation “How a Proto-oncogene Becomes an Oncogene” found at: http://www.learner.org/courses/biology/archive/animations/hires/a_cancer2_h.html (Links to an external site.)

    Another Resource Link: http://www.hhmi.org/biointeractive/p53-gene-and-cancer

5. Answer question 5 on the Student Response Sheet.

6. Answer Question 6 on the Student Response Sheet as you watch the Annenberg Media’s animation “p53’s Role in the Cell” about how one particular tumor suppressor gene works, found at:http://www.learner.org/courses/biology/archive/animations/hires/a_cancer3_h.html (Links to an external site.)                      Another Resource Link: http://www.hhmi.org/biointeractive/p53-gene-and-cancer

Learning Targets:

I can ...

• compare and contrast cellular and molecular mechanisms of normal cells and cancer cells. 
• implement advanced molecular techniques to stain normal cells and cancer cells to study under my microscope.