Activity 10.1.1 Protein Factories

Activity 10.1.1 Protein Factories

Agenda:

• Activity 4.1.2 Protein Factories

**pGLO Plasmid Slideshow: Bacterial Transformation PPT

Resources:

• NLM/NIH: https://www.nlm.nih.gov/fromdnatobeer/index.html
• Bacterial Transformation: https://www.dnalc.org/view/15918-Transformation.html
  

Agenda:

Cloning Links for your SRS:

• https://www.khanacademy.org/science/biology/biotech-dna-technology/dna-cloning-tutorial/a/overview-dna-cloning

Bacterial Transformations SRS:

• https://www.khanacademy.org/science/biology/biotech-dna-technology/dna-cloning-tutorial/a/bacterial-transformation-selection

May 10th, 2019

Activity 5.1.3: Testing Waters


Specific Agenda:

• Finish testing your water samples that includes William's well water and another water sample (can be anywhere)
• Start research short-term/long term effects of each contaminant. 
• Conclusion questions

April 24th Meets/Exceeds

Meets Links:


1. Mitosis and Meiosis Link

2. Dihybrid Cross

3. Sex Determination is in the presentation

4a. Mendelian Inheritance Pattern

4b. Non-Mendelian Inheritance Pattern
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Exceeds Links:

1. Chi-square problems in your packets

2.  Independent Assortment/Crossing over  in the presentation

3. Dihybrid cross Chi-square (we will review)

4. Thomas Hunt's experiment

Monday, April 1, 2019

Agenda: 

• Fischer's principal

• Patterns of Inheritance Presentation:
• https://drive.google.com/file/d/1qCIY1G5Ml6kvTddnEGe0h3D3bKLV1J3b/view?usp=sharing
• https://www.thoughtco.com/differences-between-mitosis-and-meiosis-373390

Resources:
Our Experiment!
https://www.khanacademy.org/science/biology/classical-genetics/chromosomal-basis-of-genetics/v/thomas-hunt-morgan-and-fruit-flies

Male/Female:

http://www.wikihow.com/Distinguish-Between-Male-and-Female-Fruit-Flies

Life Cycle:

http://skenderianscience.weebly.com/uploads/2/6/1/4/26143564/7822724_orig.jpg 

Fly Fight Club: 

http://www.hms.harvard.edu/bss/neuro/kravitz/

March 11th, 2019

Agenda:

• Unit 3 Meets/Exceeds Prep
• Finish up Skin Cancer lab

Meets Links:

Question 1: Cancer, Genes and Regulation

Cancer Presentation

P53 and Cancer

Question 2: Gene expression & DNA CHIP Analysis 

Microarray Animation 

Question 3: UVB damage and repair

Enzyme repair animation

Question 4: 

https://drjockers.com/cancer-cells/

Exceeds Links

Question 5:
https://www.hhmi.org/biointeractive/rna-interference

Question 6: 

http://www.cancer.org/cancer/cancercauses/sunanduvexposure/sun-and-uv-exposure-landing-page

http://www.skincancer.org/prevention/uva-and-uvb:

http://www.skincancer.org/prevention/uva-and-uvb/shining-light-on-ultraviolet-radiation

Question 7: 

https://www.khanacademy.org/science/biology/gene-expression-central-dogma/translation-polypeptides/a/translation-overview

Question 8: 
http://www.wormatlas.org/hermaphrodite/introduction/mainframe.htm

Agenda: 

Project 3.2.2: Skin Cancer Prevention
Resource Link: 

Three types of skin cancer: http://www.sunsmart.com.au/skin-cancer/skin-cancer-types

American Skin Cancer Society: http://www.skincancer.org/

Images of different skin cancer: http://www.cancer.org/cancer/skincancer/galleries/skin-cancer-images

UVA, UVB, UVC: http://share.upmc.com/2014/07/infographic-abcs-uv-difference-uva-uvb-uvc/

 The story of Dan: http://www.skincheck.org/Page7.php

Skin Cancer/Diseases:

http://www.mayoclinic.org/diseases-conditions/skin-cancer/multimedia/melanoma/sls-20076095

Agenda:
Activity 4.8.1 Diary of a cancer patient

Link to cancer treatments:
https://docs.google.com/presentation/d/1DznS2yuBdE2BoJB8kjfHuDYO0FOH1KvuZ2I7wA0uTQ0/edit?usp=sharing

Socratic Seminar Links:

The-Right-to-Die Debate Pew Charitable Trust 

The Economist should doctors be allowed?

The National Review: Bioethics

NPR OPB Should Physicians be allowed?

Choose a few resources below to help you complete your graphic organizer.

If you can't remember what PCR is from previous classes, try these resources:
How PCR Works interactive
YouTube intro to PCR


OK, you more or less remember what PCR is, let's chat details:
Here's Khan Academy's take on PCR
Khan Academy Video
Interactive website where you move through steps

• Unit 5: Using Model Organisms
• An Introduction to C. Elegans: 
• C. Elegans harlem shake: 
• Putting worm brains into a wormbot!

Relevant Links:

C. elegans Introductory Reading

C. elegans Student Packet

C. elegans Protocols

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RNAi Interactive Website

RNAi Graphic Organizer

Feb. 19th, 2018

• Activity 4.6.1: Finding a Match
• Tissue Typing Presentation (needed to answer conclusion questions)
• Great Video on Blood types: https://www.youtube.com/watch?v=xfZhb6lmxjk

Online Resources:

Review Blood type diagram:
https://commons.wikimedia.org/wiki/File:ABO_blood_type.svg

Review blood typing using the following website:

• Nobelprize.org’s Blood Groups, Blood Typing and Blood Transfusions: The discovery of blood groups found at: https://educationalgames.nobelprize.org/educational/medicine/landsteiner/readmore.html

Review ABO blood type genotypes using the following website:

• The University of Arizona’s The Biology Project: “Blood Types Tutorial: The Human ABO Markers – The A, B, and O alleles” found at:http://www.biology.arizona.edu/Human_Bio/problem_sets/blood_types/markers.html (Links to an external site.)

HLA Gene blood typing:

• The UC DAVIS website on HLA testing: http://www.ucdmc.ucdavis.edu/transplant/learnabout/learn_hla_type_match.html

Agenda:

• Unit 5: Using Model Organisms
• An Introduction to C. Elegans: 
• C. Elegans harlem shake: 
• Putting worm brains into a wormbot!

Relevant Links:

C. elegans Introductory Reading

C. elegans Student Packet

C. elegans Protocols

-----
RNAi Interactive Website

RNAi Graphic Organizer

PCC Visits Tuesday!!!

Activity 3.4.1 Personalized Medicine

Activity 3.4.1 Personalized Medicine

Feb. 28th, 2018

Agenda:

• Activity 4.3.1 Personalized Medicine
• TPMT VIDEO http://learn.genetics.utah.edu/content/precision/example/
• Nell's DNA sequence

Resources:

Bioserver:

http://www.bioservers.org/bioserver/

SNPs make sense:

http://learn.genetics.utah.edu/content/precision/snips/

What is Acute Lymphoblastic Leukemia (ALL):  

https://medcomic.com/medcomic/acute-lymphoblastic-leukemia/https://www.cancer.gov/types/leukemia/patient/child-all-treatment-pdq

 (Links to an external site.)at http://learn.genetics.utah.edu/content/pharma/

PLTW Cancer Center – Bioinformatics Lab

DNA Sequence Data: partial TPMT gene (840 base pairs) – acute lymphoblastic leukemia (ALL) patients

Renee

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacagg gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgaac

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

Maggie

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacaga gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgagc

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

Jada

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacagg gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgagc

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

Su

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacaga gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgaac

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

Nell

gcgggcggag gcggggcgcg gagaagtggc ggaggtggaa gcggaggcgt acccgcccct

ggggacgtca ttggtggcgg aggcaatggc cggcaaccag ctgtaagcga ggcacggaag

acatatgctt gtgagacaaa ggtgtctctg aaactatgga tggtacaaga acttcacttg

acattgaaga gtactcggat actgaggtac agaaaaacca agtactaact ctggaagaat

ggcaagacaa gtgggtgaac ggcaagactg cttttcatca ggaacaagga catcagctat

taaagaagca tttagatact ttccttaaag gcaagagtgg actgagggta ttttttcctc

tttgcggaaa agcggttgag atgaaatggt ttgcagaccg gggacacagt gtagttggtg

tggaaatcag tgaacttggg atacaagaat tttttacaga gcagaatctt tcttactcag

aagaaccaat caccgaaatt cctggaacca aagtatttaa gagttcttcg gggaacattt

cattgtactg ttgcagtatt tttgatcttc ccaggacaaa tattggcaaa tttgacatga

tttgggatag aggagcatta gttgccatca atccaggtga tcgcaaatgc tatgcagata

caatgttttc cctcctggga aagaagtttc agtatctcct gtgtgttctt tcttatgaac

caactaaaca tccaggtcca ccattttatg ttccacatgc tgaaattgaa aggttgtttg

gtaaaatatg caatatacgt tgtcttgaga aggttgatgc ttttgaagaa cgacataaaa

Learning Target:

• I can determine how SNPs in my DNA sequence effect how I can metabolize different drugs that treat cancer.